Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity.

OBJECTIVE:
To characterize the functional brain changes involved in δ-9-tetrahydrocannabinol (THC) modulation of chronic neuropathic pain.

METHODS:
Fifteen patients with chronic radicular neuropathic pain participated in a randomized, double-blind, placebo-controlled trial employing a counterbalanced, within-subjects design. Pain assessments and functional resting state brain scans were performed at baseline and after sublingual THC administration. We examined functional connectivity of the anterior cingulate cortex (ACC) and pain-related network dynamics using graph theory measures.

RESULTS:
THC significantly reduced patients’ pain compared to placebo. THC-induced analgesia was correlated with a reduction in functional connectivity between the anterior cingulate cortex (ACC) and the sensorimotor cortex. Moreover, the degree of reduction was predictive of the response to THC. Graph theory analyses of local measures demonstrated reduction in network connectivity in areas involved in pain processing, and specifically in the dorsolateral prefrontal cortex (DLPFC), which were correlated with individual pain reduction.

CONCLUSION:
These results suggest that the ACC and DLPFC, 2 major cognitive-emotional modulation areas, and their connections to somatosensory areas, are functionally involved in the analgesic effect of THC in chronic pain. This effect may therefore be mediated through induction of functional disconnection between regulatory high-order affective regions and the sensorimotor cortex. Moreover, baseline functional connectivity between these brain areas may serve as a predictor for the extent of pain relief induced by THC.
© 2018 American Academy of Neurology.

 

 

 

https://www.ncbi.nlm.nih.gov/pubmed/30185448

House Rules Committee Blocks FY19 Marijuana Amendments

My first amendment, cosponsored by Representatives Dana Rohrabacher, Barbara Lee and Earl Blumenauer, strikes the rider that prohibits D.C. from spending its local funds to commercialize recreational marijuana.  Nine states have legalized recreational marijuana, and eight of those states have approved commercialization.

In February 2015, D.C. legalized the possession of marijuana for recreational use, after two independent studies found dramatic racial disparities in marijuana arrests in D.C.  A rider to block recreational use failed due to faulty drafting, and possession of up to two ounces of marijuana for recreational use is legal in D.C., but Congress has prohibited D.C. from spending its local funds to tax and regulate recreational marijuana.  This rider has unintentionally benefited violent drug gangs.  For that reason, some refer to it as the “Drug Dealer Protection Act.”  As one marijuana dealer told the Washington Post, the rider is “a license for me to print money.”  Regulating marijuana like alcohol would allow D.C., instead of drug dealers, to control production, distribution, sales and revenues.

 

Sorgente: House Rules Committee Blocks FY19 Marijuana Amendments

Russia Says Canada Weed Legalization Is a ‘Breach’ of International Legal Obligations

U.S. Marijuana Party Kentucky

GettyImages-670841700

By Jason Lemon On 6/25/18

Russia has come out strongly against Canada’s decision to legalize recreational marijuana, calling the move a “breach” of its “international legal obligations.”

The Russian Foreign Ministry said that a number of international conventions, to which Canada is a signatory, require privy nations to restrict the use of cannabis and other drugs to only medical and scientific purposes.

“We expect Canada’s partners in the G-7 to respond to its ‘high-handedness’ because this alliance has repeatedly declared its adherence to the domination of international law in relations between states,” the ministry said in an official statement.

Last week, Canada became the second nation in the world and the first member of the wealthy G-7 to pass legislation to legalize recreational marijuana. The U.S. neighbor plans to implement the new regulations on October 17. Uruguay was the first nation to legalize recreational marijuana, with legislation passed…

View original post 550 altre parole

Weekly Legislative Roundup 6/29/18

The US Senate has been busy this week talking about marijuana policy. Senate Minority Leader Chuck Schumer (D-NY), along with Senators Bernie Sanders, Tim Kaine (D-VA), and Tammy Duckworth (D-IL), just introduced legislation called the Marijuana Freedom and Opportunity Act, to remove marijuana from the Controlled Substances Act and to provide funding for the expungement of criminal records for those with past marijuana convictions.

 

Sorgente: Weekly Legislative Roundup 6/29/18

Oklahoma: Voters Decide In Favor Of Statewide Medical Cannabis Access Law

A majority of Oklahomans today voted to enact State Question 788 — a statewide voter-initiated measure that permits doctors to use their discretion to recommend medical cannabis to those patients who will benefit from it. Oklahoma is now the 31st state to legalize and regulate the use of medical cannabis under state law.

“Public support for medical marijuana access is non-partisan,” NORML Deputy Director Paul Armentano said. “Even in a predominantly ‘red’ state like Oklahoma, it is the will of the voters to enact common sense, yet significant marijuana law reforms.”

He continued, “The ongoing expansion of compassionate medical marijuana in states like Oklahoma places additional pressure upon Congress to take action to end this existing state/federal conflict. It is time for members to move forward with legislation like The States Act or The Ending Federal Marijuana Prohibition Act, which would allow states the flexibility and autonomy to regulate cannabis as best they see fit — free from the looming threat of undue federal intervention.”

 

Sorgente: Oklahoma: Voters Decide In Favor Of Statewide Medical Cannabis Access Law

Weekly Legislative Roundup 6/15/18

A lot has happened in Congress this week. US Senate Majority Leader Mitch McConnell (R-KY) succeeded in inserting hemp legalization language into the wide-ranging Farm Bill – must-pass legislation that is approved by Congress every five years. The bill was then approved by the US Senate Agriculture, Nutrition and Forestry Committee.

The US Senate Appropriations Committee, for the first time ever, included protections for state medical marijuana laws in base Justice Department funding legislation. On the other hand, the US House Appropriations Committee rejected an amendment to protect banks that work with marijuana businesses from being punished by federal authorities.

Congresswoman Barbara Lee introduced The “RESPECT Resolution: Realizing Equitable & Sustainable Participation in Emerging Cannabis Trades” to elevate the importance of equity within the legal cannabis marketplace.

To all of our surprise, President Donald Trump expressed verbal support for recently introduced, bi-partisan legislation that seeks to codify legal protections for state-sanctioned marijuana-related activities. Similarly, members of the Congressional Black Caucus recently announced their support for marijuana law reforms to keep the federal government out of the business of prohibition and related law enforcement of marijuana.

At the state level, South Carolina voters approved a medical marijuana advisory question on the Democratic primary ballot by a margin of 81% – 19%. And The Maine Supreme Court ruled that employers don’t need to pay for medical cannabis under the state workers’ compensation system.

At a more local level, the St. Louis, Missouri circuit attorney will no longer pursue cases for marijuana in the amount of less than 100 grams. And Denver, Colorado is using marijuana tax revenue to fund after-school and summer programs.

Sorgente: Weekly Legislative Roundup 6/15/18