New Study Finds Cannabis May Help Preserve Brain Function As We Age

As we get older, the brain ages. As the brain ages, cognitive ability decreases. Short-term memory, learning new things, or devoting attention to several things at the same time becomes more difficult. Researchers have long been looking for ways to slow down or even reverse this process. Scientists at the University of Bonn and The Hebrew University of Jerusalem (Israel) have now achieved this in mice.

A new study published in Nature Medicine reports that low-doses of delta-9-tetrahydrocannabinol (THC), an active ingredient of cannabis, given to mice helped to restore and even reverse some effects of age-related decline in cognitive performance, as well as enhanced expression of synaptic marker proteins, and increased hippocampal spine density. These results are very promising for treatment and prevention of dementia and other neurodegenerative diseases.
The Endocannabinoid System and Aging
There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of a system that modulates the physiological processes underlying aging. The activity of the ECS declines during aging, as CB1 receptor expression and coupling to G proteins are reduced in the tissues of the aging brain.


CB1 receptors are proteins to which substances dock and thus trigger a signal chain. Because THC accumulates at the receptor, CB1 is also the reason for the euphoric and “”high” effects of THC found in cannabis and high-THC cannabis products. As we age, the quantity of the cannabinoids naturally formed in the brain reduces, leading to rapid aging in the brain.
The Zimmer, et al., Study
To test the effects of cannabis on the brain, Andreas Zimmer, director of the Institute of Molecular Psychiatry at the University of Bonn, worked with a team of researchers to study the effects of THC on mice.
mouseResearchers chose mice because there are some really important similarities between humans and mice. Because they are both mammals, the hippocampus and other brain parts involved with learning and memory function the same. Humans and mice also have the same proteins and biological systems, and a similar endocannabinoid system. However, mice have a relatively short life expectancy and display pronounced cognitive deficiencies even at 12-mos. old.
Mice were grouped by age (2 months, 12 months, and 18 months), along with a control group that was left untreated. Each group was tested for cognitive capacities before and after the treatment cycle. The team put the mice through several behavioral and ability tests, like the Morris water maze, to test their capacity to learn and adapt to changes in their environment, as well as their ability to remember and recognize other mice.
All of the mice, except the control group, were administered low doses of THC over a period of four weeks, via an implant.
“The treatment completely reversed the loss of performance in the old animals. It looked as though the THC treatment turned back the molecular clock.” – Prof. Andreas Zimmer, Institute of Molecular Psychiatry
To discover precisely what effect the THC treatment had on the mice, the researchers examined the brain tissue and gene activity of the treated mice. In the older mice, they found that the molecular signature no longer corresponded to that of an old animal, but was instead very similar to that of its younger counterpart.
The research team found that THC reversed the age-related cognitive decline in the 12-mo. and 18-mo. old mice. This behavioral effect was accompanied by increased synaptic marker proteins and increased hippocampal spine density. The number of links between the nerve cells in the brain also increased again, which is an important prerequisite for learning ability. In fact, the THC treatment worked so well that the performance of the 12-mo. old THC-treated mice closely resembled that of the untreated 2 mo. old mice in the control group.
These findings suggest that restoration of CB1 signaling in older people could be an effective strategy to treat ailments of the aging, such as dementia.
THC Affects the Brain Differently Depending on Maturity Level
The Zimmer et al. study made an interestingly discovery, however. The younger mice that were treated with THC performed on par with the older untreated mice. Deficiencies or an overabundance of cannabinoids can cause cognitive processing difficulties. Therefore, the THC consumed by the younger mice made it harder for them to learn and remember, but that same amount of THC consumed by the older mice helped them restore a declining internal balance of brain chemicals.
Researcher Onder Albayram was interviewed by Inverse Science, and asked what accounts for these behavioral changes. Albayram replied, “The young brain has lots of endocannabinoids, and an old brain has significantly less. That’s why when you give THC to a young brain, which can access lots of endocannabinoids, this confuses the brain. But when you give THC to old brains, they have less endocannabinoid binding affinity, so the brain experiences a plasticity change to adapt to high THC.”
The control group of mice who were only given a placebo displayed natural age-dependent learning and memory losses.

https://www.medicaljane.com/2017/05/15/new-study-finds-cannabis-may-help-preserve-brain-function-as-we-age/

MEXICO LAWMAKERS APPROVE MEDICAL MARIJUANA

THE NEW LEGISLATION IN MEXICO GIVES APPROVAL OF MEDICAL MARIJUANA FOR PATIENT USE AND FOR SCIENTIFIC RESEARCH.

The Mexican Chamber of Deputies passed some amendments to the General Health Law and the Federal Penal Code to permit the medical, therapeutic and research of marijuana, effectively legalizing medical marijuana in Mexico.

This is a major milestone in marijuana legalization, as not only is cannabis approved for patient use, but for research. For Mexico to open up the possibility of additional research is a huge win for both the patient and scientific community.

The Chamber of Deputies (Lower House of Congress) was 371 in favor and seven against with 11 abstentions. The bill now will be signed by President Enrique Pena Nieto.

With Friday’s vote, Mexico will join other nations in Latin America and 28 states in the US that allow cannabis for a variety of medical ailments.

Proponents argued in favor of legalization as a means to help the country reduce drug-related violence and misuse, President Enrique Pena Nieto agreed.

The newly approved bill allows the Health Ministry to develop the regulations for the medical use and production of products made from marijuana. Tetrahydrocannabinol (THC), the plant’s main psychoactive ingredient is also approved in the bill but products with only one percent concentration of THC will be allowed.

Under the newly approved guidelines, growing marijuana for medical and scientific purposes will not be punishable.

 IN MEXICO ONE FAMILY WOULD HAVE HELP TO CHANGE OPINIONS AND LEGALIZE MEDICAL MARIJUANA

Last year a family in northern Mexico became the voice of the country to legalize medical marijuana when the parents of a young epileptic girl, Grace Elizalde, won a court battle to import a cannabis oil for her treatment. Anecdotal evidence from other patients who suffer from seizure disorders helped to persuade the health ministry to allow Grace to try CBD oil as a treatment after exhausting all other treatment options, including surgery to sever her corpus callosum, the nerve fibers dividing two halves of her brain, the procedure only worsened her condition.

Suffering from 400 epileptic seizures every day, eight-year-old Grace Elizalde would become Mexico’s first authorized purchaser of medical marijuana.
Grace’s father, Raul Elizalde, said that the legislation represented “great progress.”

#medicalmarijuana #medicalmarijuana411 #cannabis #seizures #mexico #cannabiscommunity #cbd #cbdoil

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https://medicalmarijuana411.com/mexico-approve-medical-marijuana/

Treating Pediatric Epilepsy with Medical Cannabis: A Brief History

There has been a relatively recent surge of interest in using medical cannabis to treat pediatric epilepsy, which has created a firestorm between U.S. lawmakers and parents and caregivers, who are demanding access for their children. But the promise of cannabis treatment for epilepsy is nothing new – in fact, using cannabis to treat pediatric epilepsy was first brought to light thousands of years ago. Reflecting on this history may help understand the situation we’ve ended up in today.

Medical cannabis in ancient times

Cannabis was first used for medicinal purposes in China around 2700 BCE. Following suit, people in the Middle East, India, and Egypt also began incorporating cannabis into medical remedies. However, an Arabic physician named al-Mayusi is first credited with advocating for the use of cannabis to treat epilepsy in the 11th century.

East to West

Sir William Brooke O’Shaughnessy, considered the founder of medicinal marijuana, brought cannabis to Europe in the 19th century following his studies in India. He published a case report of a 40-day-old infant who he successfully treated with a cannabis tincture.

Following O’Shaughnessy’s findings, Sir William Gowers and Sir John Russel Reynolds treated epilepsy patients with cannabis as an adjunctive treatment to bromide, an anticonvulsant used at the time.

By the 20th century, cannabis had made its way to North America, and, in the 1930s and 1940s, researchers began studying cannabis compounds and isolating them for pharmaceuticals. However, in 1970, the US Controlled Substance Act prohibited cannabis use and production in response to a troubled sociocultural climate. So while science was making breakthroughs in understanding the molecular structure of cannabis compounds, those who could potentially benefit from the drug were prohibited from taking it.

However, science persisted, and a few clinical trials were conducted to test the safety and efficacy of cannabis for epilepsy. Sidney Cohen published the first study on cannabis and epilepsy in 1976.

Where we stand today

In the 1990s, researchers discovered how cannabis receptors work in the brain, a tremendous advancement in our understanding of how cannabis can be used to treat epilepsy. Additional research also showed that cannabidiol (CBD) was effective in reducing seizures in animal models as well as in human clinical trials.

But now it’s 2017, nearly 30 thirty years later. As a fallout from the infamous Drug War, medical cannabis use remains prohibited in many U.S. states; even in states where medical cannabis is legal, there are different rules and regulations that may limit access to the drug.

We are closer than ever to getting a clinically proven cannabis treatment approved by the FDA — which is its own potential controversy — but at least there are now several trials underway testing the effects of cannabis on pediatric epilepsy.

A doctor’s tools of the trade. Photo Credit: Andrew Malone
Fighting for their children
For some parents and caretakers, waiting a year or several years until drugs are FDA-approved is simply not good enough for their children who need help right now. Several anecdotal stories have emerged in the media in which parents and caretakers have traveled thousands of miles and risked legal consequences to obtain medical cannabis for their children.

A recent statement from the American Epilepsy Society (AES) offers the following for parents and caregivers: “The anecdotal reports of positive effects of the marijuana derivative CBD for some individuals with treatment-resistant epilepsy give reason for hope. However, we must remember that anecdotal reports alone are not sufficient to support treatment decisions…AES urges all people touched by epilepsy to consult with an epilepsy specialist and explore the many existing treatment options, so that they can make informed decisions with their specialist that weighs the risks and benefits of the different treatment options.”

Hopefully, in a year or two, we will realize a future of cannabis and pediatric epilepsy following the approval of new, cannabinoid-based therapies.

https://www.ganjapreneur.com/treating-pediatric-epilepsy-with-medical-cannabis-a-brief-history/

5 Diseases Marijuana Treats Better Than Prescription Drugs

We can all pretty much agree at this point that big pharama isn’t interested in curing people but interested in making money and having more customers. Our goal is to educated the world on the many great benefits marijuana has to offer. Here is a list of 5 diseases marijuana will actually treat more efficiently then the poison made by big pharma.

1. Epilepsy – The side effects of commonly prescribed epilepsy medications are enough to cause concern and seek alternative treatment in and of themselves.

Loss of appetite, exhaustion and depression are all related to popular prescription drugs like Clonazepam, Felbamate, Phenobarbital, Primidone and Tiagabine.

New studies are even revealing links between these prescriptions and psychoses. Marijuana however, can increase deteriorating appetites and aid restless users.

Also, depression is one of the commonly treated conditions marijuana  is known to enhance, so there’s lesser fear of increased risks.

2. Cancer – Not only does marijuana actually kill cancer cells, it inhibits the growth of cancerous tumors from the start. Cannabinoids actively attack these diseased cells, protecting users from experiencing more and more complications due to the illness.

Research has discovered that marijuana can actually deactivate the gene responsible for metastasizing cells into cancer, effectively ending the need for harsh radiation or chemotherapy treatments.

While marijuana might not be an end-all solution to cancer, scientists are positive its proactive properties slow and deteriorate any abnormal growths.

3. ADHD/ADD – The treatments for ADHD and ADD are extremely addictive and habit forming. The chances of prescription drug abuse are much higher than most other medical treatments.

Methamphetamines like Adderall, Ritalin and Vyvanse are dosed out to help quell the added stimulation and increase attention spans.

Adderall and Ritalin are commonly sold on the street as alternative forms of speed. If users do not truly need the medication, it gives them a jolt of energy that can last anywhere from six to eight hours.

Aside from the potential for abuse, these stimulant drugs have shown an increased risk of psychosis, including hallucinations. Marijuana can help to free up excess dopamine that causes the brain to be overstimulated, resulting in the ADHD/ADD diagnosis, without any harmful side effects or the potential for abuse.

4. Multiple Sclerosis (MS) – Prescription drugs used to treat multiple sclerosis are increasingly dangerous. The Food and Drug Administration (FDA) released a statement to patients using the drug Gilenya, stating that the medication led to a substantially increased risk of brain infection.

The problem with many MS treatments is they are designed to block white blood cells from attacking nerves. Normally, white blood cells protect the body from infection and disease.

When they are being blocked by these prescription drugs, they leave users at a much higher risk of developing serious illnesses that could ultimately cause more damage than the MS.

A 50/50 mixture of CBD and THC extracts has been approved in the UK and more than 20 other countries as a safer, more effective treatment of the spasticity and pain associated with MS.

5. Fibromyalgia (FM) – Marijuana has been found to be more effective at relieving Fibromyalgia symptoms than all of the leading prescription drugs.

In a study conducted by The National Pain Foundation and NationalPainReport.com, 1,300 FM patients were asked about their medical treatments. 379 participants admitted to using Marijuana therapy, and of that 379, 62% said the medication was “very effective” at reducing symptoms.

Compare that to the 10% of “very effective” results from Lyrica and Savella, and just 8% from Cymbalta.

Sorgente: 5 Diseases Marijuana Treats Better Than Prescription Drugs

6 Amazing Ways Marijuana Affects Your Body

 

1. Marijuana Modulates Neurotransmitters – Chemicals in your brain called neurotransmitters help brain cells (neurons) communicate with each other. Compounds in the marijuana plant engage these neurotransmitters and alter the chemical signaling in your brain.

Psychoactive THC impacts several different neurotransmitters in the brain. However, it’s most famous for producing a spike in feel-good chemical dopamine. Dopamine is responsible for focus, attention, pleasure, pain, and reward.

Non-psychoactive Cannabidiol (CBD) works a bit differently. It modulates the release of a variety of different neurotransmitters. When you have a little too much of something, it can calm the brain down. If you’re too low, it can restore balance and lift your mood.

 

2. Marijuana affects your blood pressure – THC is a vasodilator. This means that it opens up your blood vessels and allows more blood flow. In doing this, it lowers your blood pressure. In fact, this is why you often get red eyes when you consume the herb.

Blood vessels in your eyes have opened up, allowing more blood to flow into the area. This can be highly beneficial for anyone with eye pressure troubles, like glaucoma patients.

3. Sexual under performance in men is possible – In men, marijuana use is associated with delay or trouble with orgasm. This may also be partly caused by the interaction between marijuana compound and male sex hormones like testosterone.

Some animal research has shown that testosterone spikes and dips while you’re high and then returns to normal later on.

Similarly to women, there are many things that can throw male sex hormones out of wack. Maintaining a healthy diet and lifestyle can help ensure that you have the right hormonal balance for you prior to the effects of marijuana.

It’s also important to not that there are a lot of men out there who fully enjoy weed-induced sex. Just make sure not to smoke so much you wind up stuck on the sofa.

 

4. Marijuana heightens your senses – After consuming a little herb, have you noticed that colors look a little brighter? That the smell of food became a little more irresistible? The same blood pressure effects trigger pupil dilation, which makes colors seem a little more vivid than usual.

Animal studies have also shown that THC stimulates the olfactory bulb. This is the scent sensing area of the brain. In mice, these enhanced smelling powers led them directly to food. So, expect heightened visceral awareness from the psychoactive herb.

5. Marijuana makes you really love eating – Ever wonder where the munchies come from? THC binds to the same location as compounds that control appetite and metabolism. When you take in THC, it kicks your metabolism into overdrive.

It jump starts the production of the hunger hormone ghrelin and another hormone called leptin. Incidentally, leptin is responsible for telling your brain when to stop storing calories as fat.

At the same time, the dopamine spike from marijuana makes eating feel absolutely awesome. Dopamine is already released when we eat, but marijuana enhances the whole experience. This makes food taste awesome and wonderful to eat.

6. Marijuana increases your heart rate – Doctors often advise against using marijuana if you have a heart condition. The herb increases your heart rate for up to 3 hours after consumption. Cannabis increases heart rate a little more than sex, and about as much as strenuous exercises. But, speeding up your heart when your blood pressure is lowered can make for a bad time.

Though the plant has not caused any deaths to date, it is thought that your risk of heart attack increases when you consume marijuana. So, be mindful of heart complications when you toke up.

Marijuana is an amazing herb with ample therapeutic potential. These 7 facts are far from a complete representation of the plant.

Yet, for those who are a little canna-curious or are trying to make sense of your experiences, these are the most basic things you need to know.

Sorgente: 6 Amazing Ways Marijuana Affects Your Body

44 in Congress support effort to keep DOJ handcuffed in medical cannabis states

A bipartisan collection of nearly four-dozen U.S. House members want the feds to maintain their hands-off enforcement position toward states that have legalized medical marijuana.

Rep. Dana Rohrabacher, a Republican lawmaker from California, has spearheaded spending bill amendments that prevent the Justice Department from meddling in medical marijuana states. On Monday, he announced that he is urging the Commerce, Justice and Science committee chiefs to continue that path.

In a letter co-signed by Rep. Earl Blumenauer, D-Oregon, and 42 other House of Representatives members, Rohrabacher asked the chair and ranking member of the House Appropriations Subcommittee on Commerce, Justice, Science, and Related Agencies to include the following language in the fiscal year 2018 spending bill:

 

None of the funds made available in this Act to the Department of Justice may be used to enforce federal prohibitions involving the use, distribution, possession, or cultivation of marijuana for medical purposes that are permitted by the laws of the state, the District of Columbia, or U.S. territory where the act was committed, or to prevent states, the District of Columbia, or U.S. territories from implementing their own laws that permit the use, distribution, possession, or cultivation of marijuana for medical purposes.

 

Sorgente: 44 in Congress support effort to keep DOJ handcuffed in medical cannabis states

Sessions’ DOJ Reviewing Marijuana Enforcement Policies, Governors…

 

  • United States Attorney General Jeff “Marijuana Consumers Aren’t Good People” Sessions has issued a formal memorandum calling on members of the Justice Department’s Task Force on Crime Reduction and Public Safety to “undertake a review of existing policies,” including federal enforcement policies with regard to cannabis.

 

The memo was sent on April 5 to 94 U.S. Attorney’s Offices and Department of Justice component heads.

  • The Attorney General has requested a report back from task force members by no later than July 27th. You can read the full memo here.The release of this memorandum provides us with a general time frame during which to expect any formal announcements from the new administration with regard to addressing marijuana policy — specifically whether the Justice Department will respect state legalization laws.

    In the interim, members of Congress can remove all of the bite from Jeff Sessions’ bark by approving the bipartisan Respect State Marijuana Laws Act, which prevents the federal government from criminally prosecuting individuals and/or businesses who are engaging in state-sanctioned activities specific to the possession, use, production, and distribution of marijuana.

    Speaking recently before Congress, Attorney General Sessions said that his job is to enforce federal law. Let’s change federal law to ensure that our reform victories remain in place, and so that we can build upon these victories in the future.

    CLICK HERE TO CONTACT YOUR REPRESENTATIVE IN SUPPORT OF RESPECTING STATE MARIJUANA LAWS.

    But while the Justice Department contemplates its next move, state politicians are taking action. In recent days, Washington Gov. Jay Inslee (D), Colorado Gov. John Hickenlooper (D), Oregon Gov. Kate Brown (D) and Alaska Gov. Bill Walker (I) issued a letter to the new U.S. Attorney General and to Secretary of Treasury Mnuchin calling on them to uphold the Obama Administration’s largely ‘hands off’ policies toward marijuana legalization, as outlined in the Cole Memo.

    “Overhauling the Cole Memo is sure to produce unintended and harmful consequences,” the governors wrote. “Changes that hurt the regulated market would divert existing marijuana product into the black market and increase dangerous activity in both our states and our neighboring states.”

    Political and social change rarely comes from the top on down, it comes from the bottom up. That is why it is imperative for you to not only contact your federal officials in support of changing policy, but also to continue to push for change at the local and state level.

    Click HERE to view pending federal and state legislation and easily contact your elected officials in support of them.

    Click HERE to find a local NORML chapter in your area and get involved. NORML Kansas City this week successfully placed marijuana decriminalization on their municipal ballot and saw it pass with 71% support. This is the kind of positive change a group of committed volunteer citizens can bring to their communities.

    A people united will never be defeated and together we WILL end marijuana prohibition nationwide.

    2 Responses to “Sessions’ DOJ Reviewing Marijuana Enforcement Policies, Governors Fight Back”

    1. Frederick Oppido says:

      We need the courage of our elected officials to undo the travesty known as the War on Drugs that has been unleashed on the American people. It is time to end a policy whose very foundation is based on lies, fear, intimidation, and deceit not scientific credibility. How many more lives will be destroyed for the Crime of Feeling Good? The Crimes Against Humanity that have been unleashed on the American people are no closer to achieving their goals than when this Draconian policy became the law nearly 80 some years ago. It is time for our elected officials to step up and put an end to this American nightmare.
      The only solution is for sensible legislation that ends criminal penalties for the personal or medical use of cannabis where no crimes are committed. Legalize, Regulate, Tax it just like Alcohol and allow citizens the right to make their own decisions in regards too consumption.

    2. Julian says:

      Indeed: how about legalize marijuana worldwide:
      http://www.marijuana.com/blog/news/2017/04/new-study-mexican-children-fighting-refractory-epilepsy-with-cbd/

      How ironic that Mexico is importing marijuana from Colorado for their case studies on epilepsy. The Government farm in Mississipi and cartel brick weed have become obsolete as the quality state legal supply from Colorado and soon California floods the market…
      …unless of course youre Dr Sue Sisley who has been fighting to clear the legal hurdles to provide FDA approved cannabis to veterans with PTSD:

      http://www.marijuana.com/blog/news/2017/04/mississippis-marijuana-director-defends-cannabis-research-program/

      Sisley has to use the governments “medical” marijuana to comply with Federal law even though it fails a lead test, a mold and a yeast test.

      Perhaps Sessions is kicking the can to US attorneys in July to see if the Rorhabacher-Farr amendment gets renewed this month: or for FDA approval of synthetic marijuana to pay Congress? …or maybe its because he admits keeping the Cole memo is the only option the DOJ can afford regardless?

      Either way, this Disadministration needs to get their message straight.

      Take the recent blunder by the TSA for example:
      http://www.marijuana.com/blog/news/2017/04/tsa-speaks-on-this-mornings-medical-marijuana-confusion/

      They posted it was legal to carry weed on carry-on yesterday then abruptly took it off, said “NO” to marijuana on carry-on or checked-in luggage, then told Duke London at Marijuana.com that they “have no regulations on marijuana.” (Right… Which is why you have marijuana regulations written on the TSA website? …)
      For the Love of all that is GREEN and HOLY! Call and write Congress to DO their JOB, stop this insanity and pass the Respect State Marijuana Laws ACT.

 http://blog.norml.org/2017/04/06/sessions-doj-reviewing-marijuana-enforcement-governors-fight-back/?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+NORMLBlog+%28NORML+Blog%29

Report: Canada to legalize marijuana by July 2018

David Taylor, a spokesman for Justice Minister Jody Wilson-Raybould, declined to comment on the reported timelines. He reiterated a government pledge to unveil a proposed law by spring

By Jen Skerritt and Aoyon Ashraf, Bloomberg News

The frenzy surrounding Canada’s marijuana market intensified Monday after a report the government will unveil plans to legalize sales for recreational use in April.

Prime Minister Justin Trudeau’s government will introduce legislation the week of April 10 to legalize marijuana by July 1, 2018, according to a report from the Canadian Broadcasting Corporation. David Taylor, a spokesman for Justice Minister Jody Wilson-Raybould, declined to comment on the reported timelines. He reiterated a government pledge to unveil a proposed law by spring.

Shares of Canopy Growth Corp., the first Canadian company with a market value of C$1 billion, making it a marijuana unicorn, rose as much as 11 percent intraday in Toronto, the biggest gain since November 2016. Aurora Cannabis Inc. gained as much as 11 percent, Aphria Inc. rose 6.5 percent, and OrganiGram Holdings Inc. jumped 10 percent.

The value of Canada’s pot stocks have soared amid investor optimism that recreational sales, which Canaccord Genunity Group Inc. said in November could reach C$6 billion in sales annually by 2021, may start as early as 2018. Canopy Growth has seen its share price rise more than 300 percent in the past 12 months, while Aurora has climbed more than 400 percent.

In December, the Task Force on Cannabis Legalization and Regulation issued a report that recommends the Canadian government regulate the production of marijuana while the provinces control distribution and retail sales.

http://www.thecannabist.co/2017/03/27/canada-marijuana-legalization-stocks/76173/

INTEGRAZIONE CON CANAPA SATIVA INDUSTRIALE (ALIMENTARE) NEI PROTOCOLLI ONCOLOGICI.

la #cannabis,risulta a tutt’oggi,essere uno dei fitoterapici ad azione chemioterapica e antineoplastica naturale piu’potenti in assoluto.esplica varie azioni che possiamo sintetizzare come segue:

1-antiangiogenesi
2-anticarcinogena
3-citotossica selettiva
4-apoptotica
5-antiproliferativa
6-antimetastatica
7-ipoglicemizzante
8-anti-ipossia
9-antivirale
10-antibatterica
11-immunostimolante e immunosoppressiva (azione duale svolta da alcune singole sostanze,innalzando la concentrazione delle quali,prevale una o l’altra azione)
12-antimicotica
14-stimola la produzione di cellule NK (natural killer)
15-sedativa
16-tonica
17-antidolorifica
18-analgesica
19-anti-colesterolo cattivo
20-antiossidante
ecc ecc.


i principali componenti ad esplicare le azioni terapeutiche sono il #thc,(responsabile anche dell’effetto psicoattivo-psicotropo),i #cbd,(che svolgono attivita’sinergica per certi azioni specialmente antineoplastiche e antibiotiche,ma anche di contrasto,come nel caso dell’effetto mentale provocato dal thc,in parte azzerato dai cbd),e i #terpeni,presenti negli olii essenziali di molte piante,spezie e in alcuni frutti (guarda caso dalla spiccata azione antitumorale).
a seconda delle due varieta’principali,la #indica e la #sativa,e in base al luogo di coltivazione e ad altri fattori quali esposizione alla luce solare ecc,la concentrazione delle tre categorie di componenti principali della cannabis,subisce notevoli cambiamenti.

la indica,e’solitamente piu’ricca in thc e piu’povera in cbd,viceversa,la sativa,anche se ultimamente,grazie alle moderne tecniche di incrocio,si hanno varieta’dalle caratteristiche miste e non piu’distinguibili come la botanica imporrebbe.mi sto riferendo alle varieta’medicinali (bedrocan,bediol,bedica,bedrolite,bedrobinol),che richiedono ricetta medica,ma esiste ancora una netta differenza tra le varieta’utilizzate a livello terapeutico e quelle impiegate nell’industria tessile,alimentare e cosmetica.queste ultime,sono definite varieta’sativa industriale,e per legge,la loro concentrazione di thc,non deve superare un limite ben preciso,che solitamente si attesta attorno allo 0.2%;tanto per fare un paragone,la varieta’medicinale a piu’alto tenore di thc (bedrocan),ha concentrazioni vicine al 22% di thc.sappiamo che il thc,svolge le principali azioni terapeutiche ascritte alla cannabis,tuttavia lo fa meglio se abbinato ai cbd (effetto entourage),coi quali agisce in parte in sinergia come visto,nell’esplicare azioni antineoplastiche,alcune delle quali tipiche proprio dei cbd.or bene,la legge non impone vincoli alla concentrazione di cbd nelle varieta’industriali,poiche’non sono psicoattivi (o meglio,sono leggermente euforizzanti e sadativi).anche sul terreno terpenico la legge non pone obblighi da rispettare,e anche i terpeni esplicano azioni antitumorali degnissime di nota!


come potete vedere dall’analisi del terreno terpenico dell’olio essenziale,ottenuto da fiori della varieta’fotografata (#futura75) di #canapa sativa,la concentrazione di alcuni terpeni terapeutici e’assai apprezzabile.
la canapa sativa,(varieta futura75),contiene #myrcene,presente anche nel mango,nella verbena e nell’erba cipollina.svolge azioni quali quella antimicrobica,antisettica,analgesica,antinfiammatoria,antiossidante,antitumorale (blocca l’azione dei citocromi,le aflatossine-B ed altri promutageni imolicati nella carcinogenesi).il #mircene e’un valido antidepressivo,e agendo sulla permeabilita’della membrana cellulare,permette al thc di raggiungere prima le cellule cerebrali,potenziandone gli effetti.il mircene e’contenuto sia nella varieta’medicinale bedica (indica al 14% di thc),che nella bedrolite (thc basso).proseguendo nell’analisi del terreno terpenico della canapa industriale,troviamo il
#caryophillene,dal tipico odore di limone e balsamo,terpene che ricercano i cani antidroga delle varie unita’cinofile della GDF nell’annusare persone,indumenti e oggetti al vaglio della loro analisi olfattiva.il #cariofillene e’antinfiammatorio,degno di apprezzabili proprieta’antalgiche e anch’esso antitumorale!!
il #terpinolene,e’antinfiammatorio,antiossidante e antiproliferativo.esplica azione sedativa.
l’#humulene,che rappresenta ben il 40% dell’olio essenziale di luppolo,e’un ottimo antinfiammatorio.
e veniamo al #limonene,terpene candidato ad una varieta’infinita di applicazioni terapeutiche,dalla cura dell’aids a quella del cancro.il limonene,incrementa i livelli epatici implicati nella neutralizzazione dei metaboliti cancerogeni e promuove l’enzima #glutation-s-tranferasi,potente detossicante e chelante,preposto all’eliminazione dei metaboliti tossici e cancerogeni.distrugge le cellule tumorali.gli spray al limonene sono utilizzati contro la depressione.anch’esso,come il mircene,agisce aumentando la permeabilita’della membrana cellulare,permettendo al poco o tanto thc presente nella varieta’,di poter raggiunger prima il cervello.
ovviamente nella cannabis medicinale,vi sono ben oltre 15 terpeni ad azione antitumorale,ma anche il terreno terpenico della varieta’industriale e’interessante.
i cbd,si sono dimostrati in grado di esplicare i seguenti effetti:analgesico,antidiabetico-ipoglicemizzante,antiepilettico,antimicrobico,antibiotico,ansiolitico,tonico,sedativo,antispastico,antinfiammatorio,immunosoppressivo,neuroprotettivo,vasodilatatore,antiproliferativo e proapototico in sinergia al thc e ai terpeni.
il costo delle varieta’industriali di canapa,e’risibile se confrontato alle cugine medicinali,e si possono acquistare liberamente,senza ricetta medica,presso i canapai (nel caso della varieta’illustrata in foto,”azienda canapa delle marche”di Matteo Venturini,n.tel 328 8181791),o presso alcune erboristerie quali “l’arcobaleno”di schio di vc,della dottoressa Cristina Gentilin.
specifico che entrambi spediscono i prodotti su tutto il territorio nazionale.
la canapa industriale puo’esser fumata,utilizzata per prepararne tisane,oleoliti,tinture madri,e pietanze.mangiando canapa industriale,si convertono i cbd in thc a livello intestinale,particolare degnissimo di nota!!inoltre,anche la preparazione di oleoliti e resine puo’permettere di estrarre percentuali piu’ alte di thc,rispetto quelle indicate sulla confezione.
laddove i costi elevati delle varieta’medicinali,fossero proibitivi per alcuni malati,la canapa industriale (fiori e/o oleoliti o olio essenziale prodotti con essa),rimane un valido ripiego,come testimoniano i documenti del secolo scorso relativi all’opera del farmacista carlo erba.e’consigliabile sinergizzarne l’azione a quella di altri chemioterapici naturali quali:curcuma,whitania somnifera,aloe,mirra,liquerizia,noce moscata